PREMATURE OVARIAN FAILURE ( Premature Menopause. ) When the number of eggs in the ovary reduces dramatically, ovaries become small, and on 2nd day of menses the number of follicles in the ovary are less than 4. If we do AMH levels (ANTI MULLERIAN HORMONE) it is low < 1. All this normally happens when a women crosses 45 yrs of age – natural onset of Menopause. In some women this process starts early and menstrual cycles become irregular, scanty, sexual drive drops, and she is infertile. All the medicines like DHEAS are tried to increase ovarian reserves but not all succeed. For women with low AMH, High FSH, and Poor Antral Follicle count – IVF should be started early to get the quickest chance of Pregnancy.