The genetic integrity of the spermatozoan is essential for normal embryo development. A high level of DNA fragmentation in sperm cells may represent a cause of male infertility that conventional examinations - sperm concentration, motility analysis, morphology assessment - cannot detect. Results reported in the scientific literature show regardless of the assisted reproductive technology used, elevated levels of DNA fragmentation above the critical threshold will significantly compromise the possibility of a successful pregnancy.
High sperm DNA fragmentation does not appear to affect fertilisation or the first or second embryo cleavage stages
High sperm DNA fragmentation can affect embryo cleavage once the paternal genome is switched on, and subsequent blastocyst development
DNA fragmentation levels are closely correlated with IUI, IVF and ICSI miscarriage and pregnancy rates
DNA fragmentation is significantly higher in sub fertile men.
Men with poor semen parameters are more likely to have high DNA fragmentation
High sperm DNA fragmentation is also found in men with normal semen parameter